右美托咪定联合舒芬太尼用于结肠癌术后镇痛效果观察

Postoperative Analgesia Efficacy Observation of Dexmedetomidine Combined with Sufentanil on Colonic Cancer Patients

为观察右美托咪定与舒芬太尼联合应用于结肠癌患者术后镇痛的效果,将98例行结肠癌根治术患者随机分为对照组和观察组,每组49例。对照组予以托烷司琼和舒芬太尼进行术后镇痛,观察组在对照组的基础上联合右美托咪定进行术后镇痛,比较2组患者T1(术毕)、T2(术后4h)、T3(术后8h)和T4(术后24h)的疼痛及镇静评分、术后24h、48h和72h的切口机械性刺激疼痛敏感面积及术后不良反应发生情况。结果显示,观察组患者术后4h、8h和24h的疼痛评分明显低于对照组,镇静评分明显优于对照组(P <0.05);观察组患者术后24h、48h和72h的切口机械性刺激疼痛敏感面积明显小于对照组(P <0.05);2组患者术后不良反应发生率比较无显著性差异(P>0.05)。结果表明,右美托咪定联合舒芬太尼可有效提高结肠癌患者术后的镇痛、镇静效果。

This study was to observe the postoperative analgesia efficacy of dexmedetomidine(DEX)combined with sufentanil on colonic cancer patients,98 patients to be subject to colonic cancer surgery were randomly divided into control group(49 cases,sufentanil plus tropisetron for postoperative analgesia)and observation group(49 cases,added DEX based on control group);then compared both groups’following items such as the score on pain and sedation at T1(operation ended),T2(4 hafter operation),T3(8 hafter operation)and T4(24 hafter operation);the area of sensitivity to pain induced by mechanical stimulation at24 h,48 hand 72 hafter operation;as well as untoward reaction incidence.As results,the score on pain,on sedation at T2,T3 and T4 in observation group were significantly and respectively lower,higher than that in control group(P<0.05);the area at above time points after operation in observation group was significantly smaller than that in control group(P<0.05).There was no statistical difference in untoward reaction incidence between the two groups(P>0.05).Results show that DEX plus sufentanil can effectively enhance the postoperative analgesia and sedation efficacy on colonic cancer patients.