奥曲肽联合乌司他丁治疗小儿术后炎性肠梗阻的疗效及对血清炎症因子水平的影响

Effect of Octreotide plus Ulinastatin in the Treatment of Infantile Postoperative Inflammatory Intestinal Obstruction,and their Influence on Patients’ Serum Inflammatory Factor’s Level

为探讨奥曲肽联合乌司他丁治疗小儿术后炎性肠梗阻的疗效及对血清炎症因子水平的影响,选择2017年5月至2018年5月我科收治的100例术后炎性肠梗阻患儿,随机分为观察组和对照组,各50例,2组均接受常规对症治疗(禁食、禁水、胃肠减压、抗生素使用、肠外营养等),除此之外,对照组予奥曲肽皮下注射,观察组予奥曲肽皮下注射+乌司他丁静脉滴注。比较2组治疗效果及治疗前后患者血清白细胞介素6(IL-6)、C-反应蛋白(CRP)、肿瘤坏死因子α(TNF-α)水平。结果显示,观察组总有效率明显高于对照组,P <0.05;观察组患者肠鸣音恢复时间、肛门排气时间、腹部症状缓解时间均明显短于对照组,P <0.05。2组患者治疗前血清IL-6、CRP、TNF-α水平比较差异均无统计学意义,P>0.05;治疗后,2组血清IL-6、CRP、TNF-α水平均显著降低,其中观察组各指标水平更低,P <0.05。结果表明,术后炎症性肠梗阻患儿应用奥曲肽和乌司他丁治疗,可促进其胃肠功能恢复,降低血清炎症因子水平,效果显著。

This study was to investigate the effect of Octreotide plus Ulinastatin in the treatment of infantile postoperative inflammatory intestinal obstruction(IPIIO),and their influence on patients’serum inflammatory factor’s(SIF)level,enrolled 100 IPIIO patients treated in authors’department(2017-05-2018-05),and randomly divided them into observation group and control group,50 cases for each group;both all received routine symptomatic therapy(fast,water deprivation,gastrointestinal decompression,antibiotics use,and parenteral alimentation,etc);besides,control group was given Octreotide through subcutaneously injecting,while observation group was subcutanously injected Octreotide and intravenously injected Ulinastatin;then compared both groups’effects,and the levels of serum IL-6,CRP and TNF-αbetween before and after treatment.As results,in observation group total effective rate;the time for bowel sound recovered,for anal exhaust,for abdominal symptoms relieved were respectively significantly higher;shorter than that in control group(P<0.05).Before treatment both groups’levels of serum IL-6,CRP and TNF-αhad no statistical difference(P>0.05),but after treatment both groups’levels were all significantly declined,just the all factors’levels in observation group was more lower than that in control group(P<0.05).Results show that combination of both drugs for treating IPIIO can promote patients’gastrointestinal function recovered,decline the levels of serum inflammatory factors,and its efficacy is significant.