N-杂环卡宾钯催化硝基苯衍生物构建二芳基醚研究

N-Heterocyclic Carbene Palladium Catalyzed Nitro to Construct Diaryl Ether

为了构建二芳基醚的高效偶联反应,本文设计了一种大位阻的N-杂环卡宾钯催化剂用于催化C-O芳基化反应。论文探讨了以硝基苯衍生物为原料,N-杂环卡宾钯配体催化生成二芳基醚的研究。在优化反应条件的基础上,钯配合物C1能够在0.1mol%时高效合成一系列目标产物。

On the basis of development highly efficient protocol for Pd-catalyzed C-O cross-coupling reactions, bulky bis(imino)acenaphthene(BIAN)-supported NHC-Pd complexes was applied in the synthesis of diaryl ether. It is highlight that the iitrobenzene derivatives were selected as materials. It revealed that the bulky NHC-Pd complexe of C1 could be successfully employed in the coupling of aryl bromides at a low palladium loading of 0.1 mol %.