血清促甲状腺激素水平与胆管结石复发相关性研究

Research TSH levels and bile duct stone recurrence

目的研究血清促甲状腺激素(TSH)的高低对胆管结石复发的临床意义,对胆管结石的预防和治疗起到指导作用。方法选择本院普通外科2011年3月~2014年2月收治的120例胆管结石术后患者为观察对象。根据手术前血清TSH水平高低分为正常组(对照组)和升高组(观察组),对比胆管结石的复发率。同时观察组给予口服左甲状腺钠片,根据治疗后3个月TSH正常与否分为控制组和非控制组,对比胆管结石的复发率。结果观察组6、12、24个月的胆管结石的复发率均显著高于对照组(P<0.05);观察组中非控制组6、12、24个月的胆管结石的复发率显著高于控制组(P<0.05);控制组的12、24个月的复发率较正常组,差异无统计学意义(P>0.05);女性胆管结石复发率显著高于男性(P<0.05);高年龄组较低年龄组的胆管结石复发率比较,差异无统计学意义(P>0.05)。结论血清TSH水平与胆管结石的复发率相关,女性胆管结石的复发率较男性更高,血清促甲状腺激素(TSH)对胆管结石的预防具有指导意义。

Objective To investigate the thyroid stimulating hormone( TSH) levels and the relationship of bile duct stone recurrence,and provide a theoretical basis and clinical reference for the prevention and treatment of bile duct stones. Methods Choosing 120 patients in general surgery department of our hospital in March 2011-February 2014 who were treated bile duct stones. Preoperative detection of TSH levels,according to TSH levels divide the patients into the normal group( control group) and rise group( observation group),compare their bile duct stone recurrence rate. While observing the group left thyroid sodium tablets given orally,three months after treatment,according to TSH into the relapse rate is back to normal control group and the non-control group,compare their bile duct stone recurrence rate. Results The 6,12,24-month bile duct stone recurrence rate of observation group was obviously higher than control group( P < 0. 05); The 6,12,24-months bile duct stone recurrence rate of uncontrol group in observation group was obviously higher than control group( P < 0. 05); 12 and 24 months,the recurrence rate in the control group compared with the control group,the difference was not statistically significant( P > 0. 05); patients were more women than men bile duct stone recurrence rate is high,the differences were statistically significant( P < 0. 05); high age group lower bile duct stone recurrence rate of the age group,the difference was not statistically significant( P > 0. 05). Conclusion The TSH levels increased recurrence rate increases bile duct stones,bile duct stone recurrence rate of women higher than men,lower TSH can reduce the recurrence rate of bile duct stones,gallstones women should pay attention to the disease,regular medical examinations to prevent gallstones occurs.