开滦人群胆石症患病率调查研究

Prevalence survey of Gallstone in Kailuan study

目的探讨开滦研究人群胆石症的患病率及影响因素。方法对参加2006~2007年度健康体检的101510例开滦在职及退休职工进行调查,排除因各种原因胆囊切除者;肝功能障碍者;拒绝接受肝胆超声检查或超声资料缺失者,最终纳入统计分析的有99799例。根据超声检查结果将研究对象分为有胆石症组和无胆石症组,计算胆石症的患病率,采用多因素Logistic回归分析影响胆石症的因素。结果 (1)在99799例研究对象中,男性79603例,女性20196例,年龄为(51.90±12.67)岁。检出胆石症2363例。胆石症、胆囊结石、胆管结石、胆囊合并胆管结石的患病率分别为2.4%、2.2%、0.1%、0.04%。(2)胆石症、胆囊结石、胆管结石、胆囊合并胆管结石的不同性别的患病率分别为男性2.3%、2.2%、0.1%、0.04%;女性2.5%、2.4%、0.05%、0.05%。(3)增龄、女性、BMI、hs CRP为胆石症的危险因素,其OR值分别为1.04(95%CI 1.04~1.05)、1.25(95%CI1.12~1.39)、1.34(95%CI 1.22~1.47)、1.22(95%CI 1.14~1.30)。饮酒为胆石症的保护因素,其OR值为0.80(95%CI0.70~0.92)。结论增龄、女性、肥胖、hs CRP是胆石症的危险因素,适量饮酒是胆石症的保护因素。

Objective To investigate the prevalence and effect factors in Kailuan study of Gallstone. Methods 101510 inservice and retired employees in Kailuan Company who had participated in the 2006-2007 health examination,and all the information was obtain from the unified survey,blood biochemistry and abdominal ultrasound. Eliminating 13 participants of gallbladder removal;561 participants of liver function disorder; 1137 participants who refused to accept the abdominal ultrasound examination or ultrasound data missing,99799 participants eventually into the statistical analysis. According to the results of ultrasound examination,they are divided into two groups( participants with gallstone and participants without gallstone),computing prevalence of gallstone,the effect factors of gallstone are analyzed in multi-factor logistic regression analysis. Results( 1) The 99799 participants' average age was 51. 90 years old,79603 individuals were male and 20196 were females. There are 2363 participants with gallstone. The prevalence of gallstone,gallbladder stone,biliary stone and gallbladder stone with biliary stone are 2. 4% 、2. 2% 、0. 1% 、0. 04%.( 2) The prevalence of gallstone,gallbladder stone,biliary stone and gallbladder stone with biliary stone in different gender,Male 2. 3%,2. 2%,0. 1%,0. 04%; female 2. 5%,2. 4%,0. 05%,0. 05%.( 3) Aging,female,BMI,hs CRP are risk factors of gallstone,and the OR values of them are 1. 04( 95% CI 1. 04 ~ 1. 05) 、1. 25( 95% CI1. 12 ~ 1. 39) 、1. 34( 95% CI 1. 22 ~ 1. 47) 、1. 22( 95% CI 1. 14 ~ 1. 30).Drinking is protective factor of gallstone and its OR value is 0. 80( 95% CI0. 70 ~ 0. 92). Conclusion Aging,female,obesity,hs CRP are risk factors of gallstone,responsible drinking is protective factor of gallstone.