黄酮类化合物研究(Ⅳ)——2′羟基-4′-取代查尔酮及4′-羟基-7-取代黄酮醇的合成

Studies on Flavonoids (Ⅳ)——Synthesis of 2/-Hydroxy-4/-Substituted-Chalcones and 4'-Hydroxy-7-Substituted-Flavonols

4＇,7-二羟基黄酮醇是中草药舒冠通糖浆的主要成份之一,该药对冠心病、心绞痛、胸闷有一定疗效,为了系统研究黄酮类化合物的构效关系,我们合成了五个新的4＇-羟基-7-取代黄酮醇,同时,因为2＇-羟基-查尔酮是合成黄酮、黄酮醇及二氢黄酮的重要中间体,为进一步合成一系列7-取代黄酮类化合物,我们以2-羟基-4-取代苯乙酮为原料,又合成了8个新的2＇-羟基-4＇-取代查尔酮。

Eight new 2'-hydroxy-4'-substituted-chalcones and five new 4'-hydroxy-7-substituted-flavonols were synthesized. Their structures were proved by UV,1HNMR, MS and elemental analysis.