多脉冲激光辐照皮肤组织的光热效应实验研究

Experimental study of optical-thermal effect of skin irradiated by multi-pulse laser

通过实验测定了离体乳猪皮肤组织在多脉冲Nd:YAG激光辐照下径向和轴向不同位置的温度分布,重点研究了激光辐照能量密度、脉冲重复频率以及波长对皮肤组织温升分布的影响。研究结果表明:皮肤组织中的温度分布与探测位置、激光辐照能量密度、脉冲激光的重复频率以及波长密切相关;在激光辐照时间为40s的情况下,同一波长同一频率时组织温度随能量密度的增加而增大,波长1064nm、重复频率10Hz时的安全光剂量阈值为1118.19mJ/cm2;同一波长同一能量密度时,组织温度随脉冲激光重复频率的增加而增大;同一能量密度同一频率时,波长为1064nm的多脉冲激光辐照皮肤组织时的光热效应较532nm波长明显。

Temperature distributions of the porcine skin in the radial direction and axial direction were measured by using multi-pulse Nd:YAG laser irradiation under different wavelengths.The results show that the temperature distribution in the skin tissue is significantly affeceted by the measuring position,pulse repetitive freuqency and wavelength,and irradiation energy density.When th wavelength and repectitive frequency are definite,the temperature of the tissue inceases with the energy density,and the photo disruption threshold is 1 118.19 mJ/cm2 at the wavelength of 1 064 nm and the repetitive frequency of 10 Hz;when the wavelength and the energy density are definite,the temperature of the tissue increases with the repetitive frequency;and when the energy density and repetitive frequency are definie,the optical-thermal effect at the wavelength of 1 064 nm is more remarkable than that of 532 nm.