创面敷料用静电纺核-壳结构纳米纤维

Electrospun core-shell nanofibers potential for wound dressing

通过同轴静电纺丝方法,制备出具有核-壳结构的海藻酸钠(SA)-聚乙烯醇(PVA)纳米纤维,其中SA为核层、PVA为壳层材料。由于SA具有非常好的止血性、亲水性、无毒性和生物可降解性,故在生物材料领域具有良好的应用前景。但SA作为聚电解质,具有较高的电导率及分子间排斥力,会阻碍其静电纺丝;而PVA则能够很容易地被电纺成纳米纤维,并具有高拉伸强度、拉伸模量和耐磨性。利用扫描电子显微镜、透射电子显微镜和红外衍射光谱分别对成功制备出SA-PVA核-壳结构纳米纤维的形貌及组分进行了分析。

Core-shell structured nanofibers of sodium alginate / polyvinylalcohol( SA / PVA) were prepared via coaxial electrospinning,with SA acting as a core and PVA as a shell.Due to its very good hemostasis,hydrophilic,non-toxic and biodegradable properties,SA nanofibers show great potential in the biomedical field.However,as a polyelectrolyte with high conductivity,the repulsive force among the molecules hinders the electrospinning of SA.PVA,however,can be easily electrospun into nanofibers,and PVA nanofibers exhibit high tensile strength,tensile modulus and abrasion resistance.In this study,SA-PVA core-shell nanofibers were successfully electrospun,and the morphology and composition of the resultant fibers were characterized by SEM,TEM and FT-IR spectroscopy respectively.