摘要
以2,4-二氯苯氧乙酸(2,4-D)为模型药物,CaCl2为交联剂,采用挤压法制备了2,4-D-羽毛蛋白/海藻酸钠复合微球;借助傅里叶红外光谱仪、扫描电镜、差示扫描量热仪、X射线衍射仪表征了复合微球的形貌和结构特征;探讨了羽毛蛋白和海藻酸钠的主要交互作用力;同时考察了不同比例羽毛蛋白对复合微球载药量、包封率以及缓释性能的影响。结果表明,所制得的复合微球的粒径约为1 mm;2,4-D以非晶态较为均匀地分散在复合微球中;羽毛蛋白与海藻酸钠主要通过静电作用力、氢键结合;羽毛蛋白的加入可以改变海藻酸钠载药微球的微相结构,有利于调节复合微球的载药量、包封率以及缓释性能;复合载药微球释药规律符合Korsmeyer-Peppas动力学方程。
Feather keratin /sodium alginate microspheres were prepared by extrusion dripping method choosing 2,4-dichlorophenoxyacetic acid( 2,4-D) was as model drug and CaCl2 as crosslinking agent. Morphologies and structures of composite microspheres were characterized by FT-IR,SEM,DSC and XRD. The main interaction forces between feather keratin and sodium alginate were discussed. The effects of the mass ratio of feather keratin to sodium alginate on loading content( LC) and encapsulation efficiency( EE) was also investigated. The results indicate that,the particle size of microspheres is about 1mm. Amorphous 2,4-D is dispersed in microspheres evenly. The main interaction force between feather keratin and sodium alginate contains electrostatic effect and hydrogen bonding. Feather keratin can change the structures of composite microspheres,which is conducive to adjust LC,EE and slow-release performance. The drug releasing curves can be described by Korsmeyer-Peppas equation.
出处
《高分子材料科学与工程》
EI
CAS
CSCD
北大核心
2014年第8期150-155,共6页
Polymer Materials Science & Engineering
基金
国家自然科学基金资助项目(21176269)
广东省自然科学基金资助项目(S2012010008979)
