静电喷雾法制备羧甲基纤维素/壳聚糖液芯微胶囊

Fabrication of Carboxymethyl Cellulose/Chitosan Microcapsules by Electrospray Technique

以羧甲基纤维素(CMC)和壳聚糖(CS)聚合物为原料,采用静电喷雾技术制备了CMC/CS液芯微胶囊。研究了制备条件对微胶囊成型和尺寸的影响,并用激光扫描共聚焦显微镜、扫描电子显微镜和倒置显微镜进行了表征。将四环素与CMC溶液共混,以Al3+-CS作为凝固浴,在电压10 kV、液面距离20 mm、流速10 mL/h的条件下,制备了载药微胶囊。微胶囊的药物包封率随壳聚糖浓度增大而提高,在1.5%时达到99.5%。药物释放实验结果表明CMC/CS液芯微胶囊的释放率与pH有关,控释性能良好。

Carboxymethyl cellulose /chitosan( CMC /CS) microcapsules were prepared by electrospray. The structure,mean particles size and morphology of produced microcapsules were characterized by inverted microscope,scanning electron microscope( SEM) and confocal laser scanning microscope( CLSM). The effects of preparation conditions( such as flow rate,working voltage,the distance from needle-to-collector,coagulating bath and polyelectrolyte concentrations) on the shape and size of the microcapsules were investigated. The diameters of microcapsules were controlled from 100 μm to 110 μm by adjusting preparation conditions. Tetracycline was encapsulated in the CMC /CS microcapsules with high encapsulation efficiencies( 99. 5%). Release behaviours for tetracycline demonstrate that the microcapsules have pH triggered controlled release property.