高血压患者血清瘦素与颈动脉硬化的相关性分析

Relationship between serum leptin and carotid atherosclerosis in patients with hypertension

目的探讨高血压患者血清瘦素(leptin)与颈动脉硬化的相关性。方法选取高血压患者120例,所有患者采用彩色多普勒方法检测颈动脉窦部内膜-中层厚度(intima-media thickness,IMT)值,分为颈动脉IMT正常组、颈动脉IMT增厚组及颈动脉斑块形成组,每组患者40例。所有患者记录体重指数(BMI),记录血压、血清主要生化指标以及血清瘦素水平。结果各组BMI、血压、总胆固醇指标对比,颈动脉斑块形成组及颈动脉IMT增厚组高于颈动脉IMT正常组,差异有统计学意义(P<0.05);颈动脉斑块形成组高于颈动脉IMT增厚组,差异有统计学意义(P<0.05)。各组血清瘦素水平对比,颈动脉斑块形成组及颈动脉IMT增厚组高于颈动脉IMT正常组,差异有统计学意义(P<0.05);颈动脉斑块形成组高于颈动脉IMT增厚组,差异有统计学意义(P<0.05)。IMT与收缩压、舒张压、总胆固醇、低密度脂蛋白及血清瘦素水平呈显著正相关(P<0.05),与高密度脂蛋白呈显著负相关(P<0.05)。结论血清瘦素水平的增高很可能在高血压患者动脉粥样硬化中起显著的作用,检测血清瘦素可作为高血压患者动脉粥样硬化的评估指标。

Objective To investigate the relationship between serum leptin and carotid atherosclerosis in patients with hypertension.Methods One hundred and twenty patients with hypertension were divided into the normal carotid artery intima-medium thickness(IMT) group,the carotid artery IMT thickening group and the carotid plaque formation group,there were 40 patients in each group.All the patients recorded the body mass index(BMI),blood pressure,main biochemical indexes and serum leptin.The carotid sinus IMT values were detected by Doppler imaging in all patients.Results Compared with BMI,systolic pressure(SBP),diastolic pressure(DBP) and TC,the carotid plaque formation group and carotid IMT thickening group were higher than the normal carotid IMT group,the difference was statistically significant(P<0.05);the carotid plaque formation group was higher than the carotid IMT thickening group,the difference was statistically significant(P<0.05).Compared with serum leptin,the carotid plaque formation group and carotid IMT thickening group were higher than the normal carotid IMT group,the difference was statistically significant(P<0.05);the carotid plaque formation group was higher than the carotid IMT thickening group,the difference was statistically significant(P<0.05).There was a significant positive correlation between IMT and SBP,DBP,total cholesterol,low density lipoprotein cholesterol,serum leptin(P<0.05);there was a significant negative correlation between IMT and high density lipoprotein cholesterol(P<0.05).Conclusion The increase of serum leptin level may be one of the factors that affect the occurrence and development of atherosclerosis in hypertensive patients.The monitoring of serum leptin levels can be used as an indicator of atherosclerosis in hypertensive patients.