三阴乳腺癌CD44^+/CD24^(-/LOW)细胞与CXCR4表达的临床意义

Clinicopathologic correlation of CD44^+/CD24^(-/low) cells and CXCR4 in triple-negative invasive breast carcinoma phenotype

目的探讨CD44+/CD24-/low表型在三阴乳腺癌中的临床病理意义以及与CXCR4表达的相关性。方法根据ER、PR、Her-2表达情况将118例乳腺癌分为三阴及非三阴组,应用免疫组织化学检测其CD44、CD24及CXCR4表达情况,分析CD44+/CD24-/low表型及CXCR4在三阴乳腺癌中表达情况及其与临床病理的关系。结果 34例三阴乳腺癌肿瘤细胞CD44+/CD24-/low表型阳性率为55.9%,CD44+/CD24-/low阳性与一般临床特征不相关,但与远处转移或复发密切相关。CXCR4的表达与CD44+/CD24-/low阳性细胞成正相关。结论三阴乳腺癌的复发和远处转移可能与CD44+/CD24-/low较高的表达率有关,并且可能是由CXCR4介导的。

Objective To study the expression of CD44+/CD24-/low phenotype and CXCR4in human triple-negative invasive breast tumor tissues and assess their clinicopathological significance.Methods A total of 118breast cancer cases were classified into triple-negative and non-triple-negative breast cancers according to estrogen receptor(ER),progestogen receptor(PR),and epidermal growth factor receptor2(Her-2).The expression of CD44,CD24and CXCR4was evaluated using immunohistochemical staining. The expression of CD44+/CD24-/low and CXCR4in breast cancers and their clinicopathological correlation were analyzed.Results The positive rate of the CD44+/CD24-/lowphenotype positive rate was 55.9%in 34 cases of triple-negative breast cancer cells.The CD44+/CD24-/lowpositive rate was not correlated with general clinical characteristics,but closely related with distant metastasis or recurrence.CXCR4expression and CD44+/CD24-/lowpositive cells were positively correlated.Conclusion The recurrence and distant metastasis of triple-negative breast cancer may be associated with the elevated expression of CD44+/CD24-/lowand may be mediated by CXCR4.