叶酸修饰的磁性纳米材料在肿瘤诊断和治疗中的应用进展

Research progress of folic acid conjugated magnetic nanomaterials for cancer diagnosis and treatment

癌症是威胁人类健康的主要疾病之一,由于检测方法和治疗手段的局限,其成为全球主要的公共卫生难题。叶酸修饰的磁性纳米材料由于同时具有肿瘤细胞靶向性和磁性,不仅可以用于肿瘤组织的成像和肿瘤细胞的检测,还可以用于肿瘤患者的磁热疗、药物载体和基因载体,为肿瘤的靶向诊治提供技术手段。本文综述了叶酸修饰的磁性纳米材料在肿瘤诊断和治疗中的研究进展。

Due to the limits of detection and treatment methods,cancer is one of the major diseases threatening human health,and it is becoming a major global public health problem.Folic acid conjugated magnetic nanomaterials,with targeting and magnet capabilities,can be used for tumor tissue imaging, cancer cell detection and magnetic heat treatment and as drug carrier and gene carrier.They are thus a useful tool for the targeted tumor diagnosis and treatment.This paper reviews the research progress of folic acid conjugated magnetic nanomaterials for cancer diagnosis and treatment.