SOX18在胃腺癌中的表达及临床意义

The expression and clinical significance of SOX18 in gastric adenocarcinoma

目的探讨SOX18在胃腺癌中的表达与临床病理特征的关系,分析其在胃腺癌中的作用。方法利用免疫组织化学SP法检测60例胃腺癌及其相应(15例)远端正常胃黏膜组织中SOX18的表达。结果胃腺癌中SOX18的阳性表达率为76.7%(46/60),显著高于正常粘膜组织中的30.0%,差异具有统计学意义(P<0.05)。胃腺癌中SOX18蛋白的表达与肿瘤浸润深度、淋巴结转移及TNM分期有关(P<0.05),与患者年龄、性别、Lauren组织学分型及肿瘤分化程度均无关(P>0.05)。结论 SOX18在胃腺癌中的高表达可能与胃癌的发生、发展和淋巴结转移密切相关。

Obj ective To investigate the expression of SOX1 8 in gastric adenocarcinoma and its corre-lation with clinicopathological features.Methods The expression of SOX1 8 was detected by SP immunohis-tochemical technique in 60 cases of gastric adenocarcinoma tissues and their corresponding adjacent normal gastric tissues (n=1 5 ).Results The positive percentage of SOX1 8 protein in gastric adenocarcinoma was 76.7% (46/60),which was significantly higher than that in normal gastric mucosa tissues 30.0% (P<0. 05).The expression of SOX18 was significantly related with infiltration depth,lymph node metastasis and TNM stage (P<0.05),but not with the patient's age,gender,Lauren classification and differentiation grade (P>0.05).Conclusion The high expression of SOX18 protein may play an important role in the oc-currence,development,and lymph node metastasis of gastric adenocarcinoma.