CBX7蛋白在甲状腺乳头状癌中的表达及意义

Expression and significance of CBX7 protein in thyroid gland papillary carcinoma

目的探讨CBX7蛋白在甲状腺乳头状癌组织中的表达及其临床意义。方法收集江夏区人民医院病理科2009-2013年手术切除及活检的甲状腺乳头状癌标本40例和癌旁组织标本20例。采用免疫组织化学方法检测各组组织中CBX7蛋白的表达。并对各组免疫组织化学反应的平均光密度和平均阳性面积率做单因素方差分析和SNK(q)检验,检验水准α为0.05。结果 CBX7蛋白在癌旁组织中呈高表达,甲状腺乳头状癌中呈低表达,统计分析显示,CBX7蛋白在癌旁组织中的表达显著高于甲状腺乳头状癌(P<0.05)。结论 CBX7蛋白在甲状腺乳头状癌中呈低表达,可能与甲状腺乳头状癌的发生和发展密切相关。

Objective To investigate the expression and significance of the CBX7 protein in thyroid papillary carcinoma tissue.Methods The expression of the CBX7 protein was examined by means of S-P immunohistochemical staining in 40 cases of thyroid carcinoma and 20 cases of adjacent tissue.These samples were taken from Renmin Hospital of Jiang xia District.In this research,none of the thyroid carcinoma patients accepted radiotherapy or chemotherapy before operation.HPIAS-2000 image analysis system was used to measure the average optical density and positive area.And unifies the clinical material to carry on the total lifetime analysis Results The expression of the CBX7 protein was higher in adjacent tissue,but low in thyroid carcinoma.Image analysis demonstrated that the expression of the CBX7 protein in adjacent tissue was significantly higher than that in thyroid carcinoma(P<0.05).Conclusion The expression of the CBX7 protein is low in thyroid carcinoma,which suggests that the CBX7 protein has close relations with the occurrence and development of thyroid carcinoma.