摘要
目的:比较膦甲酸钠和α-干扰素治疗慢性乙型肝炎的临床疗效,并探讨其经济学效果。方法:90例患者随机分成两组,A组用膦甲酸钠2.4g静脉滴注.每日2次,疗程1个月;B组用α-干扰素300万IU肌肉注射,每日1次,疗程3个月.观察和比较临床效果,并运用药物经济学的成本-效果分析方法进行评价。结果:在临床症状和肝功能的改善方面,两种方案效果相近,但α-干扰素组ALT恢复正常的成本-效果比低于膦甲酸钠组;在乙肝病毒指标清除方面,膦甲酸钠组疗效较好,且HBeAg转阴的成本-效果比优于α-干扰素组。结论:膦甲酸钠和α-干扰素治疗慢性乙型肝炎均有较好疗效,在改善肝功能方面两者疗效相近,但α-干扰素具有较好的经济学效果;在抗乙肝病毒方面,膦甲酸钠疗效较好,且具有较好的经济学效果。
OBJECTIVE: To compare the clinical and economical effects of foscarnet and a - interferon in treating chronic hepatitis B. METHODS: 90 cases were randomly divided into two groups. Group A, foscarnet in a dose of 2.4g,i. v . ,b .i .d . for 1 month.Group B, α - interferon in a dose of 3 million units, im, q.d. for 3 months.The clinical effects were observed and evaluated with pharmacoeconomic cost - effectiveness analysis.RESULTS: In improving symptoms and liver function, two therapeutic regimes presented similar effect.But lower expenses were costed in unit effect of decreasing ALT in group B.In clearance of virus index, group A showed better effects and costed lower expenses in unit effect of HBeAg negative conversion .CONCLUSION; Both foscarnet and a - interferon presented fairly good therapeutic effect for chronic hepatitis B.In improving liver functions, two preparations showed similar clinical effect but α - interferon presented better economical effect .In antiviral efficacy, foscarnet showed better clinical and economical effects.
出处
《中国医院用药评价与分析》
2002年第5期282-283,共2页
Evaluation and Analysis of Drug-use in Hospitals of China
