异丙酚静脉麻醉辅助结肠镜检查的应用研究

Colonoscopy under propofol sedation and anesthesia

目的 探讨应用异丙酚作镇静麻醉辅助结肠镜检查的可行性,评价其效果和安全性。方法将2 210例结肠镜检查患者随机分为2组:麻醉组(2 000例)静脉注射异丙酚至患者进入4级镇静状态后进行结肠镜检查;对照组(210例)按常规进行结肠镜检查。观察2组检查前、检查开始后1、5、20 min和检查结束后的血压、脉搏、血氧饱和度以及检查反应和入镜时间。结果 检查过程中,麻醉组的平均收缩压各时段无明显变化(P>0.05),对照组变化明显(P<0.01)。2组的平均舒张压、脉搏和血氧饱和度在相应各时段的变化均无显著性差异(P>0.05)。麻醉组的入镜时间和检查反应明显优于对照组(P<0.01)。结论 异丙酚辅助结肠镜检查是安全有效的,其入镜时间和检查反应优于普通检查。

Objective To evaluate the effectiveness and safeness of colonoscopy under propofol's sedation and anesthesia. Methods Two thousand two hundred and ten patients were divided into two groups (1) Anesthesia group: Colonoscopy was undergone when patient was in the fourth grade anesthesia state after propofol was injected intravenous. (2) Control group:Colonoscopy was undergone without anesthesia. In two group of patients average systolic pressure, average diastolic pressure, pulse rate, blood oxygen saturation were measured before examination,1 ,5,20 minute after examination and operation end. Operation duration and reaction were recorded too. Results (1) During examination average artery blood pressure had no significant change in anesthesia group patients( P > 0. 05 ) , but the control group had(P < 0. 01 ). (2) There was no significant difference in average diastolic pressure, pulse rate and blood oxygen saturation in every stage during examination in two groups . (3) Anesthesia group had less complains and shorter operation duration compared with control group. Conclusion Colonosacopy under propofol's sedation and anesthesia is effective, safe and superior.