肝硬化患者中幽门螺杆菌感染的研究

Study on Helicobacter Pylori infection in patients with liver-cirrhosis

目的 研究幽门螺杆菌(Hp)在肝硬化患者中的感染情况。方法 肝硬化组656例,对照组600例,接受胃镜检查,采用血清学方法、快速尿素酶试验、组织学染色进行Hp检测。结果 肝硬化组Hp感染率为70％,对照组为71％。两者比较无显著性差异,而在肝硬化组中Hp阳性患者的消化性溃疡发生率、门脉高压性胃病发生率及严重程度、上消化道出血率均高于Hp阴性组。结论在肝硬化患者中Hp感染可能与消化性溃疡、门脉高压性胃病及上消化道出血的发生相关。

Objective To investigate Helicobacter Pylori (HP) infection in patients with liver - cirrhosis. Methods Hp infection was examined simultaneously in liver-cirrhosis group of 656 patients with liver - cirrhosis and control group of 600 cases with nonliver - cirrhosis by serological test, rapid urea test and histological stain. Results Hp positive rate was 70% in the cirrhosis group as compared to 71% in the None cirrhosis group (P > 0. 1). The incidence of peptic ulcer, incidence and severity of portal hypertensive gastropathy (PHG) and the incidence of upper gastrointestinal hemorrhage in Hp positive patients were higher than those in Hp negative . Conclusion Hp infection in patients with liver - cirrhosis may be related to incidences of peptic ulcer, PHG and upper gastrointestinal hemorrhage.