血浆内皮素和降钙素基因相关肽与慢性萎缩性胃炎相关性研究

Clinical research on the relationship among plasma endothelin, calcitionin gene-related peptide and chronic atrophic gastritis

目的 探讨血浆内皮素(ET)、降钙素基因相关肽(CGRP)含量与慢性萎缩性胃炎(CAG)的关系。方法 选取CAG患者118例为CAG组,慢性浅表性胃炎(CSG)30例为CSG组,健康体检者30例为对照组,用放免法检测空腹静脉血ET、CGRP含量。结果(1)CAG组血浆ET水平明显高于CSG组和对照组(P<0.01),CGRP水平明显低于CSG组和对照组(P<0.01);CSG组血浆ET水平高于对照组,CGRP水平低于对照组,但与对照组比较差异无统计学意义(P>0.05)。(2)轻、中、重度CAG患者之间血浆ET含量差异有统计学意义(P<O.05);血浆CGRP含量除中、重度CAG间差异无统计学意义(P>0.05)外,其余组间的差异有统计学意义(P<0.05)。(3)CAG患者血浆ET与CGRP含量呈显著负相关(r=-0.214,P=0.02)。结论 ET、CGRP可能参与CAG的病理生理过程,其含量的变化可能与萎缩程度有关。

Objective To investigate the relationship among the plasma ET,CGRP and chronic atroph-ic gastritis (CAG). Methods One hundred and eighteen cases with GAG, 30 cases with chronic superficial gastritis( CSG) ;30 cases healthy individuals served as control group. The levels of plasma ET,CGRP were measured by radioimmunoassay. Results (1) ET levels were significantly higher in GAG than in CSG and control (P < 0.01) ;CGRP levels were significantly lower in CAG than in CSG and control (p <0.01) ;The levels of ET in CSG were higher than in control, The levels of CGRP in CSG were lower than in control, but did not reach statistical difference (P >0. 05) . (2) The levels of plasma ET is statistically different among mild, moderate and severe CAG(P< 0.05) ;The levels of plasma CGRP is a statistical difference between mild and moderate CAG,or severe CAG(P< 0.05) ,but there is no statistical difference between moderate and severe CAG (P > 0.05). (3)The levels of plasma ET were negatively correlated with the levels of plasma CGRP (r = -0. 214,P =0.02). Conclusion It is suggested that ET and CGRP were possibly involved in the pathogenesis of CAG, and their variations in concentrations were related with the extent of CAG.