基因治疗的新型载体研究进展

Novel DNA delivery systems for the gene therapy

建立和发展一个安全及有效的载体系统对基因治疗是极其重要的。尽管病毒载体已经在临床上用于基因治疗 ,但其安全性仍然不确切。近年来 ,许多非病毒性基因载体系统已被广泛开展及应用。本综述将讨论一些新的基因载体系统 ,特别是本实验室开展研究的载体系统 ,包括细胞转导肽、电脉冲导入系统。

It is extremely important to establish and develop a safe and efficient delivery system for the gene therapy. Although the virus vectors have been used for hundreds clinical trials of gene therapy, their safety remains uncertain. Recently, more nonviral delivery systems for gene transfer have been developed and used widely. This review discussed some of the novel gene delivery systems, which are being used in our laboratory including transduction peptides, in vivo DNA electrotransfer and chitosan as DNA delivery vector