X刀与传统手术治疗脑转移瘤疗效对比分析

Curative effects comparison of X-knife radiotherapy and surgery on brain metastases

目的 :探讨X刀在脑转移瘤治疗中的临床价值。方法 :分析X刀治疗的 16例脑转移瘤患者 (2 1个病灶 ) ,脑转移瘤直径 (2 .0 7± 1.7)cm ,平均剂量 (2 8± 8)Gy ,边缘剂量 (16± 4)Gy。对比分析手术加全脑放射治疗 15例 ,直径 (3.0 7± 0 .7)cm ,平均放疗剂量 46Gy。结果 :X刀治疗组 1年生存率为 5 6.3% ,手术加全脑放疗组为 46.7% ,1年后局部肿瘤控制率分别为 81.3%和 73.3% ,1年后因神经系统疾患死亡率分别为 39%和 41%。结论 :X刀是一种安全、有效和微侵袭的治疗方法 。

Objective: It is to explore the clinical value of X ray knife on brain metastases. Methods: Sixteen patients with brain metastases of twenty one lesions treated with X ray knife were analyzed retrospectively. The diameters of brain metastases were (2.07±1.7)cm, the central doses given by X ray knife were (28±8) Gy and the peripheral doses were (16±4)Gy . As comparison, fifteen patients with brain metastasis treated with surgical resection and whole brain radiotherapy were analyzed, the diameters of the lesions were (3.07±0.7)cm, and the mean whole brain radiation dose was 46 Gy. Results: One year survival rate of X ray knife group was 56.3% and that of surgery group was 46.7%. One year local tumor control rate Of X ray knife group and surgery group were respectively 81.3% and 73.3%. One year neurological disease specific death rates of the two groups were respectively 39% and 41%. Conclusion: X ray knife is a safe, effective and minimally invasive treatment method for small brain metastases.