原发性高血压红细胞钙代谢的初步探讨

A PRIMARY STUDY ON CALCIUM METABOLISM IN ERYTHROCYTE OF ESSENTIAL HYPERTENSION

原发性高血压钙恒稳异常不仅表现在血管平滑肌,也见于其它组织细胞,尤其是血液的有形成分。本文观察了原发性高血压患者红细胞的某些钙恒稳指标,并与正常人进行了比较。结果表明:高血压患者红细胞总钙浓度较正常人明显增加,红细胞膜Ca^(2+)-ATP酶活性明显降低,胞浆钙调素含量显著降低。结果提示:高血压患者红细胞Ca^(2+)-ATP酶活性下降导致胞内Ca^(2+)浓度升高,从而增加外周血管阻力,而CaM可能是通过调节Ca^(2+)-ATP酶活性间接影响血压的。

Recent studies showed that the abnormality of calcium homeostasis inessential hypertension was revealed not only in smooth muscular cellsof blood vessel, but also in other tissues and cells, especially in formedelements of the blood. In this study, some indexes of calcium homeo-stasis in red blood cells of hypertensive persons were observed, andcompared with normal controls. The results were showed as follows:the total calcium concentration in red blood cells of essential hypertensivepatients (EHP) was higher than that of normal persons, Ca^(2+)-ATPaseactivity of calmodulin-deficient membrane was decreased significantlyin EHP, and the concentration of CaM in cytoplasma was decreasedsignificantly in EHP. The results suggested that the decreased Ca^(2+)-ATPase activity lead to higher level of cytoplasmic free Ca^(2+) andtherefore increased peripheral vascular resistance, while CaM mayinfluence blood pressure indirectly by regulating the activity of Ca^(2+)-ATPase.