摘要
目的 :通过以中医补肾活血法组方“虫草地黄活血汤”对家兔实验性动脉粥样硬化症的治疗 ,探讨该方剂对于动脉粥样硬化症尤其是动脉硬化性肾病的疗效。方法 :纯种日本大耳白兔 30只 ,随机分成空白对照组、模型组、复方丹参治疗组、虫草地黄活血汤预防组和虫草地黄活血汤治疗组 ,通过生化、组织化学、分子生物学等途径观察血脂、内皮素、尿蛋白、尿NO并检测肾组织凋亡细胞等。结果 :虫草地黄活血汤可降低动脉粥样硬化动物的血脂、内皮素及NO含量 ,并能减轻肾组织细胞凋亡和蛋白尿、降低NOS灰度 ,较模型组有显著性差异 (P <0 .0 1)。结论 :虫草地黄活血汤有防治动脉粥样硬化形成的作用 。
Objective:To investigate the effects of 'chong cao di huang huo xue tang',a traditional Chinese medicine formula, on atherosclerosis especially on atheromatous renal disease in rabbit.Methods:Thirty rabbits were divided into five groups:A)Normal control group, B) Atherosclerosis group,C)'danshen'-treated group,D)'chong cao di huang huo xue tang'preventive group,E)'chong cao di huang huo xue tang'-treated group.By using biochemistry histochemistry and molecular biology wethods,blood lipid,ET, NO and apoptosis of kidney tissue were measured.Results:'chong cao di huang huo xue tang' reduced blood lipid,ET,NO and lowered proteinuria,No and apoptosis of kidney tissue( P <0.01). Conclusion: 'chong cao di huang huo xue tang'may have some preventive and therapeutiu effects on atherosclerosis and atheromatous renal disease.
出处
《中国中西医结合肾病杂志》
2002年第12期695-698,共4页
Chinese Journal of Integrated Traditional and Western Nephrology
