摘要
目的 评价卵巢癌患者血清CA 12 5表达水平的临床意义。方法 采用酶联免疫分析和流式细胞术对 3 3例卵巢癌患者血清CA12 5浓度和癌组织 p5 3V+ 、CD44S+ 、p170 + 及DNA异倍体细胞检出率进行了检测。结果 卵巢癌患者CA 12 5浓度、p5 3V+ 和 p170 + 细胞检出率均显著高于正常对照 (P <0 .0 1) ;CA 12 5浓度和 p5 3V+ 细胞表达率随临床分期增加而逐渐升高 ;p5 3V+ 和DNA异倍体细胞检出率随CA 12 5浓度增加而逐渐升高 ,CD 44S+ 细胞检出率却逐渐降低。结论 卵巢癌患者血清CA12 5浓度与癌组织 p5 3V+ 、CD44S+ 和DNA异倍体细胞检出率、肿瘤临床分期的关系都十分密切。
Objective To evaluate the clinical significance of serum level of CA125 in patients with ovarian cancer.Methods Concentration of serum CA125 and percentage of p53V +,CD44S+,p170 + cells and heteroploid cell in tumor tissue were measured in patients with ovarian cancer by ELISA and flow cytometry.Results Concentration of serum CA125 and percentage of p53V +,p170 + cells of cancer tissues were significantly higher than those in normal controls( P <0.01).The concentration of serum CA125 and percentage of p53V + cells in tumor tissue gradually increased with the advancement of clinical stage.The percentage of p53V + cells and the positive rate of DNA heteroploid were gradually increased followed by the increase of the concentration of serum CA125,while the percentage of CD44S + cells in tumor tissue gradually decreased.Conclusion There is marked relationship between the concentration of serum CA125 and the percentage of p53V + or CD44S + cells,the positive rate of DNA heteroploid and clinical stage of patients with ovarian tumor.
出处
《实用癌症杂志》
2002年第6期602-604,共3页
The Practical Journal of Cancer
