紫杉醇联合5-氟脲嘧啶持续输注治疗晚期胃癌的临床研究

Clinical Study on Paclitaxel Combination with 5-Fluorouracil Continuous Infusion Therapy for Advanced Gastric Cancer

目的 观察紫杉醇 (PTX)联合 5 -氟脲嘧啶 ( 5 Fu)持续静脉输注治疗晚期胃癌的疗效和毒性。方法 对 3 0例晚期胃癌患者第 1、第 8、第 15天使用PTX 60mg/m2 ,静脉滴注 ;第 1～ 15天使用 5 -Fu 0 .2 5 g/m2 ,2 4h中心静脉持续输注。 2 8天为 1个周期 ,2个周期后评定疗效 ,平均 3 .43个周期。结果 2 8例可评价疗效 ,2 8例中完全缓解 3例 ,部分缓解 14例 ,总有效率为60 .7% ;中位缓解期为 6.4个月 ;中位生存期为 11.5个月。毒副作用主要为剂量限制性毒性 ,表现为骨髓抑制。结论 紫杉醇加 5-氟脲嘧啶持续静脉输注是治疗晚期胃癌较好的化疗方案。

Objective To evaluate the efficacy and toxicity of paclitaxel(PTX) combination with 5 Fluorouracil(5 Fu) continuous infusion treatment in the advanced gastric cancer.Methods Thirty patients of advanced gastric cancer were treated.The treatment schedule was consist of PTX 60 mg/m 2 iv.d1,d8,d15 and 5 Fu 0.25 g/m 2/24 h civ.d1～15.Cycles repeated for 28 days.All patients received over 2 cycles of chemotherapy,median 3.43 cycles.Results The overall response rate was 60.7%(3 complet responses and 14 partial responses were observed in 28 patients).The median response duration was 6.4 months.The median survival period was 11.5 months.The dose limiting toxicity was mild and mainly hematologic.Conclusion A high response rate was obtained in advanced gastric cancer treated by the chemotherapy.