摘要
以盐酸维拉帕米为模型药物 ,制备了口服渗透泵片。通过考察渗透泵片体外释药各过程的速率 ,研究口服渗透泵制剂释药的基本过程及其特性。结果表明盐酸维拉帕米口服渗透泵制剂的释药过程主要包括四个步骤 ,其中体外释药速率与由水渗透过膜过程所控制的药物释放速率接近 ,从而说明水渗透过膜是控速步骤。
The main processes of the drug delivery of oral osmotic pump system were studied to investigate its delivery characteristics, with verapamil hydrochloride as the model drug. The results showed that the delivery process of the oral osmotic pump system of verapamil hydrochloride mainly included four steps, and the in vitro delivery rate of the oral osmotic pump system was close to the rate controlled by the step of infiltration of water through the membrane, the latter being the control step for this system.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2002年第12期590-592,597,共4页
Chinese Journal of Pharmaceuticals
关键词
盐酸维拉帕米
渗透泵
体外释放
控缓释制剂
verapamil hydrochloride
osmotic pump
in vitro release
controlled delivery
