半夏厚朴汤抗抑郁作用的研究-Ⅰ

Antidepression Effect of Banxiahouputang Ⅰ.

目的 研究半夏厚朴汤的抗抑郁作用。方法 采用小鼠强迫游泳、悬尾、育亨宾增强、高剂量阿扑吗啡拮抗等实验动物模型 ,评价半夏厚朴汤的抗抑郁作用。结果 半夏厚朴汤 2 0 0、5 0 0 mg/ kg能显著缩短小鼠强迫游泳、悬尾不动时间 ,5 0 ,2 0 0 ,5 0 0 mg/ kg能增强育亨宾对小鼠的毒性作用 ,5 0 0 mg/ kg能拮抗阿扑吗啡降低小鼠体温作用。

AIM The purpose is to study the antidepressant effect of Banxiahouputang on animal models. METHODS The antidepressant effect of Banxiahouputang was evaluated through mice forced swimming test, mice tail suspension test,and antagonism of high dose of apomorphine and yohimbine potentiation model in mice. RESULTS Banxiahouputang significantly decreased the accumulative immobility time of mice treated with Banxiahouputang 200 and 500 mg/kg/day in mice forced swimming test and mice tail suspension test. Banxiahouputang significantly increased the death rate of mice treated with Banxiahouputang 50, 200 and 500 mg/kg/day in yohimbine potentiation model. Banxiahouputang significantly decreased the range of apomorphine-induced hypothermia in mice treated with Banxiahouputang 500 mg/kg/day. CONCLUSION Banxiahouputang had obvious effect of antidepression.