药代动力学/药效学模型在特殊人群抗菌药物治疗中的应用现状

Progress in the application of pharmacokinetic/pharmacodynamic models in antimicrobial drug treatment of special population

药代动力学/药效学(PK/PD)模型是将药代动力学和药效学结合起来研究的模型,用来描述和预测药物效应-时间过程并解释其原因,可应用于临床前和临床试验的各阶段,现已广泛用于抗菌药物的各方面研究。抗菌药物治疗中的特殊人群各自具有独特的病理、生理特征,因此临床中未能实现每位患者的个性化给药,而PK/PD模型是目前实现患者个性化给药的重要途径。本文将围绕PK/PD模型在特殊人群抗菌药物治疗中的应用进展进行综述。

The pharmacokinetic/pharmacodynamic(PK/PD)model is a model that combines pharmacokinetics and pharmacodynamics to describe and predict drug effects-time processes and explain their causes.It can be applied to various stages of preclinical and clinical trials and has been widely used in various aspects of antibacterial drugs.The special populations in antimicrobial treatment have their own unique pathological and physiological characteristics,so individualized regimen of each patient is not achieved in the clinic,and the PK/PD model is an important way to achieve personalized drug regimen.This article will review the application of PK/PD model in the treatment of antibiotics in special populations.