摘要
氨基-3-羟基-5-甲基-4-异唑丙酸(AMPA)受体作为重要的离子型谷氨酸受体亚型,广泛分布于中枢神经系统。本文概述了糖尿病认知功能障碍发病机制与AMPA受体不同亚基的关系,将有助于探索糖尿病认知功能障碍潜在治疗靶点,有利于新药的研发。
Theα-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid(AMPA)receptor is widely distributed in the central nervous system as an important ionotropic glutamate receptor subtype.This paper summarizes the relationship between the pathogenesis of diabetic cognitive dysfunction and different subunits of AMPA receptor,which will help to explore potential therapeutic targets for diabetic cognitive dysfunction and facilitate the development of new drugs.
作者
李明超
叶云
刘远
张祚
周吉银
LI Ming-Chao;YE Yun;LIU Yuan;ZHANG Zuo;ZHOU Ji-Yin(National Drug Clinical Trial Institution,The Second Affiliated Hospital,Army Medical University,Chongqing 400037,China;School of Pharmacy,Southwest Medical University,Luzhou 646000,Sichuan Province,China;Department of Pharmacy,The Affiliated Hospital of Southwest Medical University,Luzhou 646000,Sichuan Province,China)
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2019年第17期1956-1959,共4页
The Chinese Journal of Clinical Pharmacology
基金
国家自然科学基金资助项目(81770806,81471040)
重庆市基础与前沿研究计划重点课题基金资助项目(CSTC2015JCYJBX0138)
