玉泉丸汤剂联合坎地沙坦酯对糖尿病肾病患者肾功能、炎性因子和HOMA-IR的影响

Effect of Yuquan Pill Decoction Combined with Candesartan Ester on Renal Function,Inflammatory Factors and HOMA-IR in Patients with Diabetic Nephropathy

目的讨论玉泉丸汤剂联合坎地沙坦酯对糖尿病肾病患者肾功能、炎性因子和HOMA-IR的影响。方法现将2017年6月—2018年7月收治的糖尿病肾病患者80例作为研究对象,按照患者的入院时间将其分为对照组和观察组各40例,对照组仅使用坎地沙坦酯治疗,观察组则联合使用玉泉丸汤剂和坎地沙坦酯,对2组患者的肾功能、炎性因子和HOMA-IR水平进行对比和分析。结果观察组患者的肾功能、炎性因子和HOMA-IR水平均明显优于对照组,经计算发现其具有统计学意义(P <0. 05)。结论玉泉丸汤剂联合坎地沙坦酯可有效改善糖尿病肾病患者的肾功能,减轻炎症反应和胰岛素抵抗,有利于患者的恢复,可在临床上应用。

Objective To discuss the effects of Yuquan pill combined with candesartan ester on renal function,inflammatory factors and HOMA-IR in diabetic nephropathy patients. Methods From June 2017 to July 2018,80 patients with diabetic nephropathy were divided into control group( n = 40) and observation group( n = 40). The control group was only treated with candesartan ester,while the observation group was treated with Yuquan pill decoction and candesartan ester. The renal function,inflammatory factors and HOMA-IR levels of the two groups were compared and analyzed. Results The renal function and inflammation were observed in the observation group. The level of factor and HOMA-IR were significantly better than that of control group,and there was statistical significance after statistical calculation( P< 0. 05). Conclusion Yuquan pill combined with candesartan ester can effectively improve renal function,alleviate inflammatory reaction and insulin resistance in patients with diabetic nephropathy.