火针合多奈哌齐口服治疗阿尔茨海默病临床观察

Clinical Observation on Fire Needle Combined with Oral Donepezil in the Treatment of Alzheimer's Disease

目的观察火针合多奈哌齐口服治疗阿尔茨海默病(AD)的临床疗效。方法将92例AD患者随机分为实验组(46例)和对照组(46例)。实验组用火针合多奈哌齐口服治疗,对照组予多奈哌齐口服治疗,疗程为3个月。2组分别在实验前后对简易智力状态检查量表(MMSE)和日常生活能力量表(ADL)进行评分。结果实验组总有效率为82. 61%,高于对照组(63. 04%),2组比较有显著性差异(P <0. 05)。实验后实验组MMSE、ADL与对照组的MMES、ADL比较均有非常显著性差异(P <0. 01)。实验组不良反应发生率(4. 34%)低于对照组不良反应发生率(17. 39%),2组比较有显著性差异(P <0. 05)。结论火针合多奈哌齐治疗AD,不但可显著改善AD患者的总体功能、认知障碍及日常生活能力,且能降低多奈哌齐的不良反应,值得推广应用。

Objective To observe the clinical curative effect of fire needle combined with oral donepezil in the treatment of Alzheimer’s disease. Methods 92 cases of AD patients were randomly divided into experimental group( 46 cases) and control group( 46 cases). The experimental group used fire needle combined oral donepezil treatment,and the control group was treated with donepezil. The course of treatment was 3 months. Before and after the experiment,the two groups were evaluated by the simple intelligence state Checklist( MMSE)and the daily living capacity scale( ADL). Results The total effective rate of the experimental group was 82. 61%,which was higher than that of the control group( 63. 04%),and there was a significant difference between the two groups( P < 0. 05). After the experiment,the MMSE and ADL of the experimental group were significantly different from the MMES and ADL in the control group( P < 0. 01).Conclusion Fire needle and donepezil in the treatment of AD not only can improve the overall function and AD in patients with cognitive impairment and daily living ability,and can reduce the adverse reaction of donepezil,and is worthy of popularization and application.