理中汤加减治疗慢性胃炎脾胃虚寒证临床观察

Clinical Observation on Modified Lizhong Decoction in the Treatment of Spleen and Stomach Deficiency-cold Syndrome of Chronic Gastritis

目的研究探讨理中汤加减治疗慢性胃炎脾胃虚寒证的临床效果。方法选择69例慢性胃炎脾胃虚寒证患者(2017年1月—2018年7月)进行前瞻性研究,按照随机数字表法将69例患者分为对照组34例、观察组35例,对照组给予西药常规治疗,观察组给予理中汤加减治疗,比较2组的临床疗效、症状缓解时间、中医证候积分、不良反应发生率。结果观察组、对照组的临床总有效率分别为97. 14%、79. 41%,观察组高于对照组(P <0. 05)。恶心、腹痛、便溏等症状缓解时间比较,观察组均短于对照组(P <0. 05)。2组治疗后的胃脘胀痛、食少纳呆、恶心呕吐、便溏等中医证候积分均较治疗前降低(P <0. 05),而治疗后观察组的中医证候各项积分均低于对照组(P <0. 05)。观察组、对照组的不良反应总发生率分别为5. 71%、2. 94%,差异无统计学意义(P> 0. 05)。结论理中汤加减治疗慢性胃炎脾胃虚寒证患者,有效地改善了患者的临床症状,效果优于西医治疗,且不良反应少,用药安全性良好。

Objective To investigate the clinical effect of modified Lizhong decoction in the treatment of spleen and stomach deficiency-cold syndrome of chronic gastritis.Methods Choosing 69 cases of chronic gastritis patients with spleen deficiency cold syndrome(from January2017 to July 2018)prospectie study,according to random number table method,69 patients were divided into control group of 34 cases and observation group of 35 cases.The control group was given conventional western medicine treatment,and the observation group was given in modified Lizhong decoction.The clinical curative effect,relieve symptoms,TCM syndrome integral,the incidence of adverse reactions was compared.Results The total clinical effective rate of the observation group and the control group was 97.14%and 79.41%,respectively.Compared with the control group,the observation group was higher than the control group(P<0.05).The remission time of nausea,abdominal pain,stool and other symptoms was shorter in the observation group was shorter than that in the control group(P<0.05).After treatment,the scores of TCM syndromes such as epigastric distension,shaona retention,nausea and vomiting,and loose stool in both groups were lower than those before treatment(P<0.05),while the scores of TCM syndromes in the observation group after treatment were lower than those in the control group(P<0.05).The total incidence of adverse reactions in the observation group and the control group was5.71%and 2.94%,respectively,and there had no statistically significant difference between the two groups(P>0.05).Conclusion Lizhong decoction in the treatment of chronic gastritis patients with spleen and stomach deficiency-cold syndrome can effectively improve the clinical symptoms of patients,the effect is better than western medicine treatment,and has less adverse reactions and good drug safety.