补肾保胎助孕汤治疗肾虚型胎漏及胎动不安临床观察

The Clinical Study of Bushen Baotai Zhuyun Decoction in the Treatment of Vaginal Bleeding During Pregnancy and Threatened Abortion Caused By Kidney Deficiency

目的探讨补肾保胎助孕汤在肾虚型胎漏及胎动不安患者中的临床效果。方法选择2017年6月—2018年10月治疗的肾虚型胎漏及胎动不安患者86例作为研究对象,按随机数字表法分为对照组(43例)和观察组(43例)。对照组给予地屈孕酮治疗,观察组在对照组基础上联合补肾保胎助孕汤治疗,比较2组临床效果。结果观察组治疗10 d后近期疗效率为97. 67%,高于对照组76. 74%(P <0. 05);观察组治疗后10 d血清P、E2、β-HCG水平均高于对照组(P <0. 05);观察组与对照组治疗后新生儿畸形、低体质量儿发生率比较均无统计学差异(P> 0. 05);观察组治疗后足月妊娠率高于对照组(P <0. 05);观察组治疗后早产、流产率均低于对照组(P <0. 05)。结论将补肾保胎助孕汤用于肾虚型胎漏及胎动不安治疗中能获得较高的近期疗效,能改善患者内分泌激素水平,提高妊娠结局,值得推广应用。

Objective To investigate the clinical effect of Bushen Baotai Zhuyun decoction in the treatment of vaginal bleeding during pregnancy and threatened abortion caused by kidney deficiency.Methods 86 cases of patients with vaginal bleeding during pregnancy and threatened abortion caused by kidney deficiency treated from June 2017 to October 2018 were selected as subjects.They were divided into the control group(n=43)and the observation group(n=43)by random number table.The control group was treated with diprogesterone,and the observation group was treated with Bushen Baotai Zhuyun decoction on the basis of the control group.The clinical effects of the two groups were compared.Results In the observation group,the short-term efficacy rate of observation group was 97.67%after 10 days of treatment,which was higher than 76.74%in the control group(P<0.05).Serum levels of P,E2 and-hcg in the observation group were all higher than those in the control group 10 days after treatment(P<0.05).There was no significant difference in the incidence of neonatal malformation and low birth weight between the observation group and the control group(P>0.05).The pregnancy rate of observation group was higher than that of control group(P<0.05).The rates of preterm birth and abortion in the observation group were lower than those in the control group(P<0.05).Conclusion Bushen Baotai Zhuyun decoction can obtain relatively high short-term efficacy in patients with vaginal bleeding during pregnancy and threatened abortion caused by kidney deficiency,improve the level of endocrine hormone in patients,and improve the pregnancy outcome,which is worthy of promotion and application.