加减小续命汤治疗急性进展性缺血性中风30例

Modified Xiaoxuming Decoction in the Treatment of Acute Progressive Ischemic Stroke for 30 Cases

目的观察基于玄府理论的加减小续命汤治疗急性进展性缺血性中风的临床疗效及安全性。方法将60例急性进展性缺血性中风患者随机分成观察组和对照组各30例,对照组予以抗血小板、稳定斑块、改善脑循环等一般治疗,观察组在一般治疗基础上给予加减小续命汤煎服,共治疗2周,观察2组的临床疗效、中医证候分布及改善情况和安全性。结果治疗后,观察组的中医证候总有效率为93. 33%,对照组的中医证候总有效率为73. 33%,差异具有统计学意义(P <0. 05)。治疗后观察组的内风、内火、痰湿、血瘀等中医证候要素均改善明显(P <0. 05),在内火、痰湿、血瘀方面改善优于对照组(P <0. 05);治疗后2组NIHSS评分及hs-CRP、FIB均比本组治疗前显著降低(P <0. 05),观察组上述评分及指标均优于对照组(P <0. 05)。治疗后2组均未见不良反应。结论基于玄府理论的加减小续命汤治疗急性进展性缺血性中风疗效显著、安全。

To observe the clinical effect and safety of modified Xiaoxuming decoction in the treatment of acute progressive ischemic stroke.Methods 60 cases of acute progressive ischemic stroke patients were randomly divided into observation group and control group,with 30 cases in each group.The control group was given antiplatelet and stable plaques,improve cerebral circulation general treatment.The observation group was given modified Xiaoxuming decoction on the basis of general treatment.The treatment continued 2 weeks.The clinical effects,distribution and improvement of TCM symptoms and safety were observed.Results After treatment,TCM symptom of the observation group and the control group was 93.33%,and 73.33%respectively,and the difference was statistically significant(P<0.05).After treatment,endogenous wind,fire,phlegm,dampness,blood stasis of TCM symptoms such as elements were improved significantly(P<0.05),including fire,phlegmy wet,blood stasis in the observation group improved better than that in control group(P<0.05).After treatment,the NIHSS score,hs-CRP and FIB of the two groups were significantly lower than that before treatment(P<0.05),and the above scores and indicators in the observation group were better than those in the control group(P<0.05).No adverse reactions were observed in both groups after treatment.Conclusion Xiaoxuming decoction based on xuanfu theory is effective and safe in the treatment of acute progressive ischemic stroke.