尿绒毛膜酶在糖尿病患者早期肾损害的筛检价值

The Screening Value of Urinary Brush Border Membrane Enzyme for the Early Renal Damage in Patients with Diabetes

目的探讨应用尿绒毛膜酶诊断糖尿病 (DM)患者的早期肾损害。方法对 86例 DM病人 ,77例糖耐量低减(IGT)和 15 6例正常对照组进行尿 β2 - m和尿绒毛膜酶检测。结果与对照组相比 ,尿 β2 - m仅在 DM组差异有显著性 (P<0 .0 5 ) ;尿绒毛膜酶在 DM组和 IGT组差异均有显著性 (P<0 .0 5 )。尿绒毛膜酶的筛检价值要高于尿 β2 - m。结论尿绒毛膜酶检查是 DM肾损害的早期检测手段之一 ,对 IGT、DM的早期肾损害诊断较 β2 -

Objective To explore methods for early diagnosis in diabetes complicated with renal damage. Methods 86 cases with DM, 77 cases with impaired glucose tolerance (IGT) and 156 controls were investigated. Their morning urine samples were analyzed for contents of urinary Beta 2 microglobulin and urinary brush border membrane enzyme. Results The contents of Beta2 microglobulin and urinary enzyme were higher in 86 cases with DM than in 156 controls( P <0 05), but there was no significant difference in Beta2 microglobulin between IGT and controls. The content of urinary brush border membrane enzyme of IGT was significantly higher than that of the controls ( P <0 05). The screening value of urinary brush border membrane enzyme was better than that of urinary Beta2 microglobulin. Conclusion The detection of urinary brush border membrane enzyme is one of the early methods for diagnosing renal damage of diabetes mellitus, and it is better than that of the urinary Beta2 microglobulin in IGT and DM.