塞来昔布对膝骨性关节炎的疗效及副作用观察

Observation of therapeutic effect and Adverse Reactions of Celecoxib in treatment of Osteoarthritis of Knee Joint

目的 :观察塞来昔布 (Celecoxib)对膝骨性关节炎的疗效及副作用。方法 :塞来昔布组 5 6例 ,剂量2 0 0mg·d-1;双氯芬酸钠组 30例 ,剂量 15 0mg·d-1,分 3次口服。疗程均为 6周 ,观察膝骨关节炎疼痛缓解程度、关节功能恢复状况、关节积液肿胀消退状况及服药期间出现的副作用。结果 :塞来昔布和双氯芬酸钠对膝骨关节疼痛比较P >0 .0 5 ,差异无显著性。胃肠道副作用明显比双氯芬酸钠少 (χ2 =9.74 0 ,P <0 .0 0 5 )。结论 :塞来昔布对膝骨关节炎疼痛及关节功能恢复与双氯芬酸钠最大治疗剂量相当 ,对关节积液的吸收及关节肿胀消退作用明显 。

Objective: To observe the therapeutic effect and adverse reactions of celecoxib in treatment of osteoarthritis of knee joint. Method: 56 cases of group A taking celecoxib 200 mg daily; 30 cases of group B taking diclofenac sodium 150 mg daily in three divided. The therapeutic courses of both groups were 6 week. The mitigated extent of pain, the recovery of joint function, the decrease of joint swelling, and adverse reactions during the drug used were observed.Results: The difference between two groups were not significance on the pain of knee joint( P >0.05), the adverse reactions of celecoxib were less than diclofenac sodium. Conclusion: Celecoxib and the maximum permitted dosage of diclofence sodium have a equal therapeutic effects on the pain of knee joint and the recovery of knee joint function. Celecoxib has obvious therapeutic effects on the absorption of hydrarthrosis and the decrease of joint swelling, and a good toleration on gastroenteric tract.