干燥综合征伴发其他皮肤病的临床分析

Clinical Analysis of Relationship Between Sjgren′s Syndrome and Other Assoc iated Skin Diseases

目的探讨干燥综合征与伴发其他皮肤病的相关性。方法回顾性分析了13例干燥综合征伴发其他皮肤病的临床资料,并对其临床表现、实验室检查和病因进行了分析。结果13例患者中男1例,女12例,平均年龄35.3岁。伴发皮肤病有:扁平疣、天疱疮、扁平苔藓、白癜风、带状疱疹、单纯疱疹、系统性红斑狼疮。结论干燥综合征发病与自身免疫有关,所伴发的皮肤病多与免疫有关,但两者合并发生有何内在联系,有待进一步研究。

Objective To investigate the relationship between Sjgren′s synd rome and associated other skin diseases. Methods Clinical features, laboratory a nd histopathological findings and causes were analyzed retrospectively in 13 cas es of Sjgren′s syndrome. Results Thirteen patients were studied, including 1 male and 12 female, the mean age of onset was 35.3 years old. All 13 cases prese nted features of xerostomia and xerophthalmia. The diagnosis was confirmed by po sitive Schirmer′s test, corneal fluorescein staining, and sialography. The asso ciated other dermatoses were verruca planae, pemphigus, lichen planus, vitiligo, herpes zoster, herpes simplex and systemic lupus erythematosus. All cases were treated with Chinese traditional and western medicines. Twelve cases improved ma rkedly, one eventually died of liver and renal failure and circulation failure. Conclusions The pathogenesis of Sjgren syndrome may be linked to autoimmunity, and immunological aberration has been implicated in most of associated skin dis eases. The intrinsic relationship between Sjgren syndrome and associated other dermatoses needs further investigation.