1996-2001年广州地区淋球菌耐药性和质粒介导耐药株流行趋势

Prevalence of Resistant Neisseria gonorrhoeae and Plasmid-mediated Resistant Strains in Guangzhou, 1996-2001

目的研究1996-2001年广州地区淋球菌耐药性和质粒介导耐药株流行趋势。方法采用琼脂稀释法测定淋球菌的抗生素耐药性和质粒介导的四环素耐药淋球菌(TRNG),用纸片酸度法测定质粒介导的产青霉素酶淋球菌(PPNG)。结果6年来,共检测了793株临床分离的淋球菌菌株,发现青霉素的耐药率由1996年的57.2%上升到2001年的81.8%,PPNG的流行率则由2%升至21.8%;四环素耐药率较高且稳定,但TRNG流行率由1996年1.5%增至2001年的27.2%。结论广州地区质粒介导的青霉素和四环素耐药株流行率呈现逐年上升趋势,已成为这些抗生素耐药株的高流行区。

Objective To investigate the prevalence of resistant Neisseria gon orrhoeae and plasmid-mediated resistant strains in Guangzhou from 1996 to 2001. Methods The resistant N.gonorrhoeae and plasmid-mediated resistant strains to tetracycline (TRNG) were determined using agar dilution method, and penicillinas e-producing N. gonorrhoeae (PPNG) by acidometric method. Results A total of 793 gonococcal isolates were tested from 1996 to 2001. The resistant rate for penic illin increased from 57.2%to 81.8%and PPNG from 2%to 27.2%, respectively, du ring the six years. Resistance to tetracycline remained high and stable over the years, while the rates of TRNG were increased from 1.5%to 27.2%. Conclusions The prevalence of plasmid-mediated resistant strains of N. gonorrhoeae increase s year by year in Guangzhou. These results suggest that the clinical isolates of gonococcal strains in this city are highly resistant to penicillin and tetracyc line.