硅基纳米材料结合阿司匹林的缓释作用研究

Functions of the Silicon-based Nanometer Material Combining Aspirin

本文在碱性条件下,硅酸钠作为硅源,十六烷基三甲基溴化铵(CTAB)作为结构模板剂,利用水合晶化法合成了纯硅源的MCM-41介孔分子筛.采用浸渍法将阿司匹林组装在MCM-41六方形孔道中,制备出新型载药Aspirin/MCM-41复合物。采用X射线粉末衍射(XRD)和傅里叶红外光谱(FT-IR)表征手段对合成的新型功能化介孔材料进行表征。MCM-41分子筛与阿司匹林的相互作用为研发以MCM-41分子筛为载体的载药体系提供了理论依据。

Mesoporous molecular sieves MCM-41 is synthesized with CTAB as template and sodium silicate as silica source in the basic condition. The grafting of method has got out of phase was used. And the loading drugs compounds Aspirin / MCM-41 was prepared by the Aspirin was encapsulated in the hexagonsl ordered channels of MCM-41 using pickling process. Assemblies were characterized by XRD,FT-IR. The strong interactions between the Aspirin and MCM-41 provided the theory for developing a novel delayed release drug using MCM-41 as the carriers.