正清风痛宁注射液电致孔透皮给药配合护理干预治疗椎动脉型颈椎病32例临床观察

Clinical observation of Zhengqingfengtongning Injection transdermal delivery by electroporation plus nursing intervention therapy in treating 32 cases with cervical spondylosis of vertebral artery type

目的观察正清风痛宁注射液电致孔透皮给药配合护理干预治疗椎动脉型颈椎病的临床疗效。方法 63例椎动脉型颈椎病患者随机分为治疗组32例和对照组31例,治疗组采用正清风痛宁注射液电致孔透皮给药、口服氟桂利嗪配合护理干预治疗,对照组仅口服氟桂利嗪治疗,10 d为1个疗程。结果治疗组总有效率为81.3%,对照组为58.1%,2组比较差异有统计意义(P<0.05);2组治疗后颈性眩晕症状与功能评估量表(ESCV)积分均显著改善,与治疗前比较,差异有统计意义(P<0.05);治疗后治疗组ESCV积分与对照组比较,差异有统计意义(P<0.05)。结论正清风痛宁注射液电致孔透皮给药配合护理干预治疗椎动脉型颈椎病有较好的疗效。

Objective To observe the efficacy of Zhengqingfengtongning Injection transdermal delivery by electroporation plus nursing intervention therapy in treating cervical spondylosis of vertebral artery type( CSA).Methods 63 cases were randomly divided into treatment group( 32 cases) and control group( 31 cases).Zhengqingfengtongning Injection transdermal delivery by electroporation,oral administration of flunarizine plus nursing intervention therapy were given to the treatment group,while the control group took flunarizine orally. 10 days was one course. Results The total effective rates of the treatment group and the control group were 81.3% and 58.1% respectively,there was a significant difference( P<0.05). Cervical vertigo and ESCV scores of two groups were improved obviously after treatment,the difference had statistical significance( P<0.05). There was also a significant difference in comparing the ESCV scores of two groups after treatment( P < 0. 05). Conclusion The combined therapy shows fairly good effect in treating CSA.