抗痫煎剂治疗症状性癫痫全身性强直-阵挛发作型的临床研究

Clinical Study on KangXian Decoction in Treating Symptomatic Epilepsy of Generalized Tonic-clonic Pattern

目的:观察抗痫煎剂治疗症状性癫痫全身性强直-阵挛发作的临床疗效、中医辨证分型的疗效差异以及脑电图的改变情况。方法:将症状性癫痫全身性强直-阵挛发作患者124例分为2组各62例,对照组患者口服卡马西平片0.1~0.2 g/次,3次/d;治疗组在对照组治疗的基础上加用抗痫煎剂,早晚各服100 m L,2组均治疗3个月为1个疗程,1个疗程后进行疗效评定。结果:2组总有效率比较差异有统计学意义(P<0.01),治疗组优于对照组;同一证型治疗组与对照组有效率比较,风痰闭阻型差异有统计学意义(P<0.01),痰火扰神型差异有统计学意义(P<0.05),血虚生风型、心脾两虚型、肝肾阴虚型差异均无统计学意义(P>0.05);在改善脑电图方面治疗组亦优于对照组(P<0.05)。结论:抗痫煎剂对症状性癫痫的全身性强直-阵挛发作型有较好的抗痫作用,以风痰闭阻型、痰火扰神型尤佳。

Objective: To observe clinical effects of KangXian decoction in treating symptomatic epilepsy of generalized tonic-clonic pattern, the difference between curative effects of syndrome differentiation and patterns and the changes of EEG. Methods: All 124 patients were randomized into two groups, 62 cases each group, the control group took carbamazepine tablets orally, 0.1~0.2 g each time, three times per day; the treatment group accepted KangXian decoction on the basis of the therapy the control group received, 100 m L, in the morning and evening,three months were one course of the treatment for both groups, clinical effects were evaluated in one course of the treatment. Results: The treatment group was superior to the control group in the comparison of total effective rates between both groups, and the difference was significant(P<0.01); the difference showed statistical meaning in the comparisons of the effective rates between the treatment group and the control group in the same pattern:wind-phlegm obstruction pattern(P<0.01), the difference had significant meaning in the comparison of the pattern of phlegm-fire disturbing mind(P<0.05), the difference had no significant meaning in the comparisons of blood deficiency causing wind, dual deficiency of heart-spleen, liver-kidney Yin-deficiency(P>0.05); the treatment group was superior to the control group in improving EEG(P<0.05). Conclusion: KangXian decoction is effective in the treatment of symptomatic epilepsy of generalized tonic-clonic pattern, especially wind-phlegm obstruction and phlegm-fire disturbing mind pattern.