摘要
本文研究了抗人胃癌McAb ID1-2在体外介导的小鼠腹腔巨噬细胞对肾癌肿瘤细胞(GGC-8140)的杀伤作用。结果表明,在McAb的介导下异种巨噬细胞杀伤靶细胞的作用明显增加。McAb可能是通过其FC段与巨噬细胞上的FC受体结合而增强对靶细胞的杀伤作用参与抗肿瘤的免疫应答。
In the present experiment, the authors investigated the effect of monoclonal antibody (GMG1:1D1-2 ) against human gastric cancer on the in vitro cytotoxicity to gastric cancer cells GGC-8140 by murine peritoneal macrophages.The results showed that opsonization of target cells by monoclonal antibody 1D1- 2 markedly enhanced the percentage of cytotoxicity of heterogenous macrophage. HE staining revealed that the target cells were wrapped up and lysed and there was a significant decrease in the number of target cells. These findings suggested that monoclonal antibody may take part in antitumor immune responses by mediating cytotoxicity of heterogenous macrophages.
关键词
巨噬细胞
肿瘤细胞
单克隆抗体
antibody, monoclonal
macrophage
tumor cell
cytotoxicity
