六通道光纤传感药物溶出度监测仪的研制及应用

Development and Application of Six-Channel Fiber Optic Sensing Drug Dissolution Monitor

药物溶出度试验是药品检验的重要项目,在药物质量评价方面起着非常重要的作用。利用光纤传感技术可以实现药物溶出度的自动化、过程化监测。以氙灯、氘灯或卤钨灯作为荧光、紫外光及可见光的光源,以Y型分支光纤作为光路传输介质,紫外-可见吸收探头或荧光分子探头作为光响应器件,CCD作为检测器,通过自编软件实现紫外-可见吸收及荧光猝灭两种模式的检测。光纤传感药物溶出度监测仪不但解决了目前离线取样分析方法耗时、耗力的缺点,而且提供了药物溶出过程的实时信息,为药物质量控制提供了更好的评价手段。

The drug dissolution test is an important examination of drug testing,which plays a very important role in the drug quality assessment.Automation and proceduring monitoring of drug dissolution can be implemented by the optical fiber sensing technology.Two modes of detection of UV-Vis absorption and fluorescence quenching were established by software implementation,with xenon lamp,deuterium lamp or halogen tungsten lamp as fluorescence,UV and visible light source,branch Y type optical fiber as light path transmission medium,UV-Vis probe and fluorescence molecular probe as light response devices,and CCD as detector.Optical fiber sensing drug dissolution monitor not only solves the current problems of time-consuming,and sampling of off-line analysis,but also provides real-time information of drug dissolution process.Thus,our study may provide a better evaluation method for the drug quality control.