傅里叶变换红外光谱技术诊断恶性肿瘤的研究进展

Recent Progress in Diagnosis of Malignant Tumors by Fourier Transform Infrared Spectroscopy

恶性肿瘤严重威胁人类的健康和生命,因此其早期诊断显得尤为重要。近年来,傅里叶变换红外光谱技术在诊断恶性肿瘤方面显示出了巨大的潜力。与传统方法相比,该技术在诊断肿瘤方面具有准确、快速、无创、原位、廉价、自动化、可重复、无需预处理、能够在分子水平上早期诊断等显著优势。本文综述了FTIR技术应用于诊断呼吸、消化、泌尿、生殖、神经、皮肤、血液等各系统恶性肿瘤方面的研究进展,并结合国际上临床医学、光谱学和化学计量学的学科发展现状提出了五点展望:扩大样本量,进行多中心研究;与内窥镜、穿刺活检结合,实现术中实时原位诊断并指导活检;进一步实现自动化;找寻更为高效的化学计量学方法;个别指认比较困难的光谱参数的识别尚有待进一步研究证实。随着FTIR技术的进一步发展和完善,它必将成为一种辅助诊断恶性肿瘤的重要方法,甚至可能作为肿瘤的常规筛查手段并应用于其分期分级中。

Malignant tumors pose a serious threat to mankind health and life .As a result ,early diagnosis is very important .In recent years ,Fourier transform infrared spectroscopy has shown enormous development potential of cancer diagnosis .Compared with traditional methods ,this technology has apparent advantages in the aspects of accuracy ,rapidity ,noninvasion ,in situ , cheapness ,automation ,replication ,without pretreatment and early diagnosis at the molecular level .This paper summarized study progress that FTIR technology applied in diagnosis of respiratory system tumor ,digestive system tumor ,urinary genital system tumor ,brain tumor ,skin tumor and blood system tumor ,and combined with the international present state of clinical medicine ,spectroscopy and chemometrics ,five prospects were put forward :expand the sample size and undertake multi-center study ;combined with endoscopy and puncture biopsy to guide real-time in situ diagnosis and biopsy during surgery ;further au-tomated ;find more efficient chemometric methods ;the identification of individual parameters has yet to be confirmed by further studies .With the further development and improvement of FTIR technology ,it will become an important method for the diagno-sis of malignant tumors ,and may even as a routine screening tool applied to stage and grade the tumors .