乌司他丁对腹部手术后细胞因子及肾功能的影响

The Effect of UIT on Function of Kidney and Cell Factors after Abdominal Operation

目的 :观察乌司他丁对腹部手术后细胞因子及肾功能的影响 .方法 :4 0例病人随机分为对照组(2 0例 )和治疗组 (2 0例 ) ,治疗组在术前第 1d ,术后 1,2 ,3d给予 2 0万U乌司他丁微量泵持续静脉泵入 ,同时检测血和尿α微球蛋白、血肌酐和尿素氮、细胞因子 .结果 :腹部大手术运用乌司他丁后 ,治疗组的血尿α微球蛋白、血肌酐、细胞因子低于对照组 .结论 :乌司他丁能抑制腹部大手术后细胞因子释放 。

Objective: To study the effect of UTI in relieving operative damage after abdominal operation. Methods: control group 20 cases and treating group 20 cases . Treating group was injected with 200?000 units UTI constantly pumping through vein by micro-pump in 1 day before operation and on 1, 3, 5?day after operation. Urinary and blood α1-MG, blood BUN, Scr, TNF, IG, IL-6, AND IL-8 were investigated in both groups. Results: The kidney functions were damaged during abdominal operation. The level of urinary and blood α1-MG TNF,IL-6,IL-8 of treating group didn't change. Conclusion: The patients can be protected by UTI in abdominal operation.