听觉诱发电位指数、双频指数和边缘频率与丙泊酚镇静作用的相关性研究

Correlation analysis of auditory evoked potentials index,bispectral index and 95% spectral edge frequency with propofol-induced sedation

目的 分析听觉诱发电位指数 (A line○R ARX indexAAI)、双频指数 (BIS)、95 %边缘频率 (95 %SEF)与丙泊酚镇静作用的相关性。方法 选择 18例ASAⅠ～Ⅱ级 ,在下胸腰段硬膜外阻滞下行妇科手术的成年病人。监测AAI、BIS和 95 %SEF ,依据OAA/S评分法评估镇静程度。术中分次静注丙泊酚 ,每隔 3分钟 2 0mg ,直至OAA/S评分达到 1分。分析AAI、BIS、95 %SEF与OAA/S评分值之间的相关性。结果 AAI、BIS、95 %SEF随病人镇静程度加深明显降低 ,且与OAA/S评分值显著相关 (诱导期Spearman’s等级相关系数r =0 95 8、0 898、0 82 0 ,P <0 0 0 1;恢复期r =0 94 6、0 70 2、0 6 14 ,P <0 0 0 1)。诱导期和恢复期AAI的相关系数与其他两者之间差异皆有高度统计意义 (P <0 0 1)。结论 AAI、BIS和 95 %SEF均可较好地反映丙泊酚的镇静效果。

Objective To analyze the correlation of the autoregressive model with exogenous input extracted auditory evoked potentials index(A line ○R ARX index AAI),bispectral index(BIS) and 95% spectral edge frequency(95%SEF) with propofol induced sedation.Methods Eighteen ASAⅠ Ⅱ adult patients undergoing elective gynecological surgery under low thoracolumbar epidural anesthesia were randomly studied.An intravenous bolus dose of propofol(20mg) was administered every 3min until the score level 1 of the observers assessment of the alertness/sedation scale(OAA/S) reached.AAI,BIS,95%SEF were monitored on different OAA/S score levels and their correlation with propofol induced sedation was analyzed.Results AAI,BIS and 95%SEF were distinctly reduced as patientsOAA/S scores decreased,and correlated with sedation significantly (during the onset phase,the coefficients of Spearmans rank correlation r= 0 958,0 898,0 820, P< 0 001;during the recovery phase, r= 0 946,0 702,0 614, P< 0 001).AAI correlated better than BIS and 95%SEF( P< 0 01) with the scores.Conclusion AAI,BIS and 95%SEF all correlated well with propofol induced sedation quantitatively and accurately. [