脑囊虫病治疗前后淋巴细胞亚群变化的研究

The Study of Lymphocytes Subgroups in Neurocysticercosis after and before Treatment

目的 研究脑囊虫病患者治疗前后淋巴细胞亚群的变化。方法 采用碱性磷酸酶桥联酶标法(APAAP)检测治疗前、后该病患者淋巴细胞亚群的变化。结果 治疗前脑囊虫病患者CD_3^+、CD_4^+、CD_8^+淋巴细胞百分率及CD_4/CD_8比值分别为58.12±6.03、33.23±4.09、28.01±2.32、1.31±0.19,显示CD_3^+、CD_4^+淋巴细胞百分率明显降低,CD_4/CD_8比值亦降低。治疗后分别为68.32±6.03、38.07±5.89、27.91±3.02、1.42±0.28,均已趋于正常。结论 囊尾蚴感染可导致患者免疫功能低下,免疫调节功能紊乱,呈免疫抑制状态。当脑囊尾蚴感染患者接受合理有效的抗囊虫病治疗后,随着体内囊尾蚴的逐渐死亡,患者免疫功能恢复正常。

Objective To Study the effects of T lymphocyte after infecting cysticercus. Methods The fluctuation of T cell subgroup of thirty patients with neurocysticercosis were detected with Alkaline phosphatase anti - Alkaline phosphatase. Results Before treatment, the percentages of CD3+, CD4+ , CD8+ lymphocytes and the CD4/CD8 ratio of patients were 58.12 ± 6.03, 33.23 ± 4.09, 28.01±2.32, 1.31±0.19, respectively. After treatment, they were 68.32±6.03, 38.07±5.89, 27.91±3.02, 1.42± 0.28. the percentages of CD3+ , CD4+ lymphocytes in peripheral blood of the patients with neurocysticercosis were obviously lower and the CD4/CD8 ratio was also low. Conclusion These indicated that before treatment, the immunoregulation function and immunocom-petence of the patients were very poor. After effective anti - cysticercus treatment, along with the dying of cysticercus, the immunoregulation function and immunocompetence of the patients returned to normal.