胃癌靶向治疗的研究进展

Progress of targeted therapy in gastric cancer

胃癌是最常见的恶性肿瘤之一,分子靶向治疗药物包括:表皮生长因子受体(EGFR)抑制剂、血管生成抑制剂、c-Met抑制剂、m TOR抑制剂、基质金属蛋白酶抑制剂、胰岛素样生长因子受体抑制剂、热休克蛋白90抑制剂、细胞周期蛋白依赖性激酶抑制剂以及多靶点酪氨酸激酶抑制剂等。本文综述近期胃癌分子靶向治疗的研究结果及相关进展。

Gastric cancer is one of the most common malignant tumors. With the research progress of gastric cancer, molecular targeted therapy has been gradually applied in the treatment of gastric cancer. Targeted therapy mainly includes: epidermal growth factor receptor(EGFR) inhibitors, angiogenic inhibitors, c-Met inhibitors, m TOR inhibitors, matrix metalloproteinase inhibitors, insulin like growth factor receptor inhibitors, heat shock protein 90 inhibitors, cyclin dependent kinase inhibitors and multiple targets tyrosine kinase inhibitors. This paper reviews the research on gastric cancer molecular targeted therapy and related progress.