肺癌合并慢性阻塞性肺疾病发病机制研究进展

Research progress on the pathogenesis of lung cancer with chronic obstructive pulmonary disease

肺癌和慢性阻塞性肺疾病(COPD)为全球性高发病率、高死亡率疾病。除烟雾暴露等易感因素外,两者间还存在包括遗传易感性和慢性炎症等其他共同致病危险因素,并有研究提示COPD是肺癌发病的独立危险因子。本文综述两者潜在的共同发病机制研究进展。

Both lung cancer and chronic obstructive pulmonary disease(COPD) are the diseases of high morbidity and mortality worldwide.Beside of cigarette smoke exposure,they may also share other common risk factors such as genetic predisposition and chronic inflammation.Currently,the increasing studies reveal that COPD is an independent risk of lung cancer.This review discusses the data presented in the literature on the pathogenesis of lung cancer with COPD.