阿尔茨海默病睡眠障碍研究进展

Research progress of the sleep disorder in Alzheimer's disease

睡眠障碍是阿尔茨海默病(AD)患者常见的临床症状而血清载脂蛋白E4及外界因素等可能是AD睡眠障碍的危险因素。AD睡眠障碍的特点包括片段化睡眠,夜间睡眠时间减少,日间思睡,严重的甚至表现为昼夜节律颠倒以及睡眠呼吸障碍等。AD睡眠障碍治疗包括非药物治疗,以及包括乙酰胆碱酯酶抑制剂、褪黑素、镇静催眠药、抗精神病药物等在内的药物治疗。本文主要综述AD睡眠障碍的特点及治疗进展。

The sleep disorder is a common symptom in Alzheimer's disease(AD) patients, which is characterized as the nocturnal sleep fragmentation, nocturnal sleep duration decreasing, diurnal napping, the even inversion of sleep-wake cycle and breathing disorder. Generally, the apolipoprotein epsilon E4 and environmental factors are responsible for the sleep disturbance in AD patients. The treatment of sleep disorder for the elderly AD patients is consisted of non-drugs therapy and drug therapy including cholinesterase inhibitors, melatonin, hypnotics and antipsychotics. This article reviews the characteristics and treatment progress of sleep disorder in AD.